Selected Publications – Fanning Lab

Nature Reviews Neurology 2025 Oct 1

Saranna Fanning, Dennis Selkoe

JCI Insight 2025 Jun 3: e188413
Stearoyl-CoA-Desaturase Inhibition normalizes brain lipid saturation, alpha-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
Silke Nuber, Harrison Hsiang, Esra’a Keewan, Tim E Moors, Sydney J Reitz, Anupama Tiwari, Gary P H Ho, Elena Su, Wolf Hahn, Marie-Alexandre Adom, Riddhima Pathak, Matthew Blizzard, Sangjune Kim, Han Seok Ko, Xiaoqun Zhang, Per Svenningsson, Dennis J Selkoe, Saranna Fanning

Neurobiol. Dis. 2024 Jul 4:106593
Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism
M A Adom, W N Hahn, T D McCaffery, T E Moors, X Zhang, P Svenningsson, D J Selkoe, S Fanning, S Nuber

Mol. Cell 2019 Mar 7;73(5):1001-1014.e8.
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Saranna Fanning, Aftabul Haque, Thibaut Imberdis, Valeriya Baru, M Inmaculada Barrasa, Silke Nuber, Daniel Termine, Nagendran Ramalingam, Gary P H Ho, Tallie Noble, Jackson Sandoe, Yali Lou, Dirk Landgraf, Yelena Freyzon, Gregory Newby, Frank Soldner, Elizabeth Terry-Kantor, Tae-Eun Kim, Harald F Hofbauer, Michel Becuwe, Rudolf Jaenisch, David Pincus, Clary B Clish, Tobias C Walther, Robert V Farese Jr, Supriya Srinivasan, Michael A Welte, Sepp D Kohlwein, Ulf Dettmer, Susan Lindquist, Dennis Selkoe

NPJ Parkinsons Dis. 2022 Jun 9;8(1):74
Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy
Saranna Fanning, Haley Cirka, Jennifer L Thies, Jooyoung Jeong, Sarah M Niemi, Joon Yoon, Gary P H Ho, Julian A Pacheco, Ulf Dettmer, Lei Liu, Clary B Clish, Kevin J Hodgetts, John N Hutchinson, Christina R Muratore, Guy A Caldwell, Kim A Caldwell, Dennis Selkoe

Acta Neuropathol. 2021 Apr;141(4):491-510
Vesicle trafficking and lipid metabolism in synucleinopathy
Saranna Fanning, Dennis Selkoe, Ulf Dettmer

NPJ Parkinsons Dis. 2020 Jan 3;6:3
Parkinson’s disease: proteinopathy or lipidopathy?
Saranna Fanning, Dennis Selkoe, Ulf Dettmer